Association between four SNPs on chromosome 9p21 and myocardial infarction is replicated in an Italian population
نویسندگان
چکیده
منابع مشابه
Validation of the association of genetic variants on chromosome 9p21 and 1q41 with myocardial infarction in a Japanese population.
BACKGROUND Recent large-scale genome-wide association studies have identified several loci associated with the risk of coronary artery disease (CAD). The aim of the present study was to examine whether the previously reported CAD-associated single-nucleotide polymorphisms (SNPs) confer susceptibility to myocardial infarction (MI) in a study population of 2,475 controls and 589 cases of MI. The ...
متن کاملAuthor's response to reviews Title: Common genetic variants on chromosome 9p21 are associated with myocardial infarction and type 2 diabetes in an Italian population Authors:
Francesca Gori ([email protected]) Claudia Specchia ([email protected]) Silvia Pietri ([email protected]) Luisa Crociati ([email protected]) Simona Barlera ([email protected]) Monica Franciosi ([email protected]) Antonio Nicolucci ([email protected]) Stefano Signorini ([email protected]) Paolo Brambilla ([email protected]...
متن کاملAssociation of variation in the chromosome 9p21 locus with myocardial infarction versus chronic coronary artery disease.
BACKGROUND A chromosome 9p21 locus is associated with coronary heart disease in 25 independent populations, but multiple clinically distinct phenotypes have been evaluated. Using angiographic coronary artery disease (CAD) phenotyping, this study evaluated whether 9p21 single-nucleotide polymorphisms predict ischemic events (eg, myocardial infarction [MI]) among CAD patients. METHODS AND RESUL...
متن کاملTwo chromosome 9p21 haplotype blocks distinguish between coronary artery disease and myocardial infarction risk.
BACKGROUND Variants at the 9p21 locus associate with the risk of coronary artery disease (CAD) or myocardial infarction (MI). However, atherosclerotic plaque deposition is distinct from MI (plaque rupture and thrombosis), and recent studies showed no association between these variants and MI in patients with preexisting CAD. We performed haplotype analysis at the 9p21 locus to test whether hapl...
متن کاملChromosome 9p21 polymorphism is associated with myocardial infarction but not with clinical outcome in Han Chinese.
BACKGROUND rs1333049 polymorphism on chromosome 9p21 has been shown to affect susceptibility to coronary artery disease (CAD) in Caucasians. This study examined the association of rs1333049 with myocardial infarction (MI), angiographic severity of CAD and clinical outcome after a first acute MI in Han Chinese. METHODS rs1333049 polymorphism was genotyped in 520 patients with a first acute MI ...
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ژورنال
عنوان ژورنال: Journal of Human Genetics
سال: 2007
ISSN: 1434-5161,1435-232X
DOI: 10.1007/s10038-007-0230-6